منابع مشابه
Noncoding RNAs in mental retardation.
Recent genome-wide interrogations of transcribed RNA have yielded compelling evidence for pervasive and complex transcription throughout a large majority of the human genome. Tens of thousands of noncoding RNA transcripts have been identified, most of which have yet to be functionally characterized. Along with the revelation that noncoding RNAs in the human genome are surprisingly abundant, the...
متن کاملnoncoding rnas and cancer
the eukaryotic complexity involves the expression and regulation of genes via rna-dna, rna-rna, dna-protein and rna-protein interactions. recently, the role of rna molecules in the regulation of genes in higher organisms has become more evident, especially with the discovery that about 97% of the transcriptional output in higher organisms are represented as noncoding rnas: rrna, snornas, trna, ...
متن کاملNoncoding RNAs
Recent years have witnessed many remarkable discoveries in the life sciences that have led to major paradigm shifts. An example is the emerging appreciation of the critical role of noncoding RNAs in a broad range of physiological and pathological processes. One such class of noncoding RNAs, the microRNAs (miRNAs), controls intricate networks of gene expression via post-transcriptional mechanism...
متن کاملLong Noncoding RNAs in Aging
Aging is associated with increasing the risk of disease and death. Recently, increasing evidences suggest that many long noncoding RNAs (lncRNAs) function through specific interactions with other cellular factors, namely proteins, DNA, and other RNA molecules. LncRNAs play important roles in a wide range of age-related diseases, such as cancer, cardiovascular pathologies, and neurodegenerative ...
متن کاملLong noncoding RNAs in hematopoiesis
Mammalian development is under tight control to ensure precise gene expression. Recent studies reveal a new layer of regulation of gene expression mediated by long noncoding RNAs. These transcripts are longer than 200nt that do not have functional protein coding capacity. Interestingly, many of these long noncoding RNAs are expressed with high specificity in different types of cells, tissues, a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Genetics
سال: 2009
ISSN: 0009-9163,1399-0004
DOI: 10.1111/j.1399-0004.2008.01134.x